Some Known Factual Statements About (-)-Cytisine - CAS 485-35-8 - Calbiochem - 505227 - EMD

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Laburnum, which consists of cytisine. It revealed teratogenic impact in bunnies and poultry. quitting smoking timeline is a respiratory stimulant, with nicotine-like activity, and a hallucinogenic. However, pharmacologically, cytisine appears to be a potential therapeutic energy in aiding smoking cessation. In addition, it has shown analgesic, antihypertensive, inotropic, antispasmodic, antioxidant, and insecticidal activities.

The results of hazardous dosages include weakness, lightheadedness, impairment of motor coordination, muscular facial twitches, increased reflex level of sensitivity, mydriasis, shallow breathing, occasional urinary retention, and eventually, tonic-clonic convulsions followed by collapse and coma with respiration cessation, primarily triggered by paralysis of breathing muscles. 485-35-8 C11H14N2O C1C2CNCC1C3=CC=CC(=O)N3C2 Harborne JB, Baxter H and Moss GP (1999 ).

2nd edition, TJ International Ltd, Padstow, UK. Rouden J, Lasne MC, Blanchet J, and Baudoux J (2014 ). Review: ()-Cytisine and Derivatives: Synthesis, Reactivity, and Applicationserome. Chem. Rev. 114: 712778. Tutka P, Zatoski W (2006 ). Evaluation - Cytisine for the treatment of nicotine dependency: from a particle to therapeutic efficacy. Medicinal reports 58,777-798.

Cytisine, N-formyl-Cytisine Baptitoxine, Sophorine Smoking Cessation Drug MoleculeSkeletal FormulaStock Vector - Illustration of formula, chemical: 187174098


Synthesis and initial medicinal assessment of some cytisine derivatives. Farmaco, 1999, 54, 438451.

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Cytisine for Cigarette Smoking Cessation: A Literature Review and a Meta-analysis Etter JFArch Intern Medication. 2006; 166:1553 -1559 To evaluate the effectiveness of an alkaloid derivative of the plant Cytisus laburnum L., or golden rain tree, called cytisine (not to be puzzled with cytosine or cysteine), a review of the literature and a meta-analysis were conducted.

The research studies, all from Bulgaria, Germany, Poland, and Russia, involved an overall of 4404 cigarette smokers treated with cytisine and 3518 controls. Quit/abstinence rates, based on survey (not biochemical) assessment, ranged from 13. 8% to 70% anywhere from 15 days to 14 months following treatment with cytisine. Meta-analysis of the 3 placebo-controlled trials exposed a chances ratio (OR) of 1.

21-3. 06) for short-term outcome of 4 weeks. A different meta-analysis of the 2 placebo-controlled trials that had long-lasting follow-up found a pooled OR of 1. 83 (95% CI, 1. 12-2. 99) for continued abstinence after 3-6 months. One placebo-controlled research study reported abstaining rates 2 years post cytisine treatment with an OR of 1.

29-2. 43). The most common type of cytisine is a tablet containing 1. 5 mg of the active ingredient. Suggested dosage is 6 tablets per day (overall of 9 mg of cytisine) for the first 3 days with a gradual taper to 2 tablets daily by day 25 at which point the treatment is stopped.


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