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Certain elements of personal skin care items such as lavender vital oil or tea tree oil and specific dietary supplements such as dong quai and have been associated with gynecomastia. عملية تثدي الرجال [edit] Individuals with kidney failure are frequently malnourished, which may contribute to gynecomastia advancement. Dialysis might attenuate malnutrition of kidney failure.

In individuals with liver failure or cirrhosis, the liver's ability to correctly metabolize hormonal agents such as estrogen may be impaired. Furthermore, those with alcoholic liver illness are even more endangered for development of gynecomastia; ethanol may directly interrupt the synthesis of testosterone and the presence of phytoestrogens in alcohols may also add to a higher estrogen to testosterone ratio.

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A small proportion of male gynecomastia cases might be seen with rare inherited disorders such as spine and bulbar muscular atrophy and the really rare aromatase excess syndrome. Testicular tumors such as Leydig cell growths or Sertoli cell tumors (such as in Peutz, Jeghers syndrome) or h, CG-producing choriocarcinoma might lead to gynecomastia.

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Individuals with prostate cancer who are treated with androgen deprivation treatment might experience gynecomastia. Pathophysiology [modify] Pathology: A big glandular mass of male breast tissue, surgically got rid of The causes of typical gynecomastia stay unpredictable, but are thought to arise from an imbalance between the actions of estrogen and androgens at the breast tissue.

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As in women, estrogen stimulates the development of breast tissue in males. In addition to directly promoting male breast tissue growth, estrogens indirectly decrease secretion of testosterone by reducing luteinizing hormone secretion, resulting in decreased testicular secretion of testosterone. Additionally, estrogens can increase blood levels of the protein sex hormone-binding globulin (SHBG), which binds free testosterone (the active kind) resulting in decreased action of testosterone in male breast tissue.

Klinefelter syndrome is a significant example of a condition that triggers hypogonadism and gynecomastia, and has a greater danger of breast cancer in males (2050 times greater than males without the disorder). Central hypogonadism (suggesting a problem with the brain) causes decreased production and release of luteinizing hormonal agent (LH, a stimulatory signal for endogenous steroid hormone synthesis) which causes reduced production of testosterone and estradiol in the testes.