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Like the EPA, after the COVID-19 pandemic started, the FDA unwinded its arrangements in order to speed up the production of hand sanitizers. Under the Federal Food, Drug, and Cosmetic Act (FD&C Act), manufacturers of hand sanitizers are considered to be "over the counter drug producers" and must register their centers with the FDA.

The FDA's temporary policy offered assistance to entities that were not presently FDA-registered drug makers on how to produce hand sanitizer. To name a few requirements, the FDA needed that makers working under this policy produce hand sanitizer that (1) consists of ethanol (or isopropyl alcohol), glycerin, hydrogen peroxide and sterilized water; (2) does not include any active ingredients to enhance its taste or odor; and (3) is a liquid solution and not a gel, foam or aerosol spray.

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The FDA has mentioned that it does not plan to initiate enforcement actions versus business that produce hand sanitizer throughout the pendency of the pandemic if those business closely follow the FDA's guidance. Commercial Cleaning Business includes following the FDA's requirements for identifying hand sanitizers; and to reduce the burden, the FDA supplied sample labels as an appendix to the guidance.

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Products that are registered as hand sanitizers by the FDA may not be utilized or signed up as a surface disinfectant by EPA. In late Might 2020, EPA provided a compliance advisory to "address issues related to items being utilized to sanitize surfaces which consist of claims to kill and/or be reliable against SARS-Co, V-2, the coronavirus triggering the illness COVID-19." After reiterating its pesticide assistance under FIFRA, EPA encouraged, "It is unlawful for anyone to disperse or offer a pesticide in the United States making claims that it will eliminate a particular pathogen, unless that pesticide is signed up with EPA which specific claim has actually been considered appropriate by the agency." In specific, EPA specified that it is concentrated on "possibly incorrect or misleading claims, including effectiveness claims," and is" dealing with e-commerce platforms to remove/prohibit these deceptive and/or otherwise inefficacious products from the marketplace." On June 11, 2020, EPA announced a stop sales order against lots of "unregistered, misbranded, or restricted-use pesticides, and pesticide gadgets that make incorrect or deceptive claims," discovered on two prominent e-commerce platforms.